Glass Lab News

  • Congratulations to Isidoro Cobo and his co-authors for publication of their paper, 'Monosodium urate crystals regulate a unique JNK dependent macrophage metabolic and inflammatory response' in Cell Reports!

  • 2021

  • Congratulations to Marten Hoeksema who starts a new postdoctoral fellow position at the University of Amsterdam with his European Commission's Marie Curie returning fellowship.
  • Aug2021
  • Congratulations to Lindsay Milich for being awarded a two-year fellowship from the UCSD NIA T32 AD and related dementias training program!

  • Congratulations to Ty Troutman, Eric Kofman et al. on their publication of Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease in Molecular Science!
  • >> Free download link until Oct 19:
  • We are very excited that Carly Dacosta has joined our lab as part of the UCSD Medical Scientist Training Program (MSTP) sponsored Summer Undergraduate Research Fellowship (SURF) Program. Carly investigates the impact of lysosomal dysfunction on microglia gene expression. Welcome Carly!

  • Hunter Bennett successfully defended his Thesis “Interrogating in vivo Mechanisms of Kupffer Cell Transcriptional Regulation Using Natural Genetic Variation”. He will now be returning to clinical clerkships at UCSD to finish his M.D.

  • Congratulations to Marten Hoeksema, Zeyang Shen, Inge Holtman, Nathan Spann, Isidoro Cobo et al. on their publication of Mechanisms underlying divergent responses of genetically distinct macrophages to IL-4 in Science Advances!
  • May2021
  • Congratulations to Zeyang Shen for successfully defending his Thesis titled "Investigating the Effects of Genetic Variation on Transcriptional Regulation". Zeyang will go on to join Prof. Julie Segre's lab as a Postdoctoral Fellow at the NIH Translational and Functional Genomics Branch.

  • Sydney O’Brien has joined the Lab as a Staff Research Assistant. Sydney will be working on the role of transcription factors regulating lysosomal activity in microglia. Welcome!

  • Congrats to Ty Troutman on having accepted a position as Assistant Professor in the Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center.

  • Enchen Zhou successfully defended his PhD thesis 'Novel Pathways in Cholesterol Metabolism to Combat Cardiometabolic Diseases'. Congratulations!
  • Mar2021
  • Congrats to Glass lab graduate students Chris Balak and Eric Kofman on each being awarded the competitive National Science Foundation Graduate Research Fellowship (NSF-GRFP)! The prestigious award supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing Ph.D./graduate research degrees and provides them with 3 years of funding.

  • Congratulations to Jason Seidman for matching to the UCSD Dermatology Residency program!

  • Lab alumnus David Gosselin awarded Canadian Institutes of Health Research Grant, 'Delineation of the epigenomic mechanisms underlying microglial transcriptional and cellular activity in demyelinating brain disorders’. Congratulations David!
  • Feb2021
  • Enchen Zhou has joined the Lab as a Postdoctoral Fellow. Enchen will be working on LXR, macrophages, and their role in the development of cardiometabolic diseases. Welcome!

  • Welcome to new Glass Lab rotation student, Hannah Mummey. Hannah will be working with Zeyang Shen to use neural network models to learn the sequences important for enhancer activation in Kupffer Cells from mice fed a NASH-promoting diet.
  • Jan2021

  • Congratulations to Alexi Nott, Johannes Schlachetzki, Bethany Fixsen et al. on their publication of Nuclei isolation of multiple brain cell types for omics interrogation in Nature Protocols!

  • 2020


  • Welcome to the Glass Lab, Joy Zhou. Joy will be working on spatial transcriptomics of tissue-resident and recruited macrophages in tissues.
  • Oct2020
  • We welcome to the Lab two new rotation students, Thomas Le and Ryan Shepard.
  • Thomas will be working together with Zeyang Shen on analyzing transcription factor binding motifs.
    Ryan will be working alongside Claudia Han on characterizing granulocyte function in brain tumors and investigating mechanisms of gender differences in the prevalence, progression, and outcomes of glioblastoma.

  • We are proud to announce that Inge Holtman, who was a postdoctoral fellow with the Glass lab 2016-2019, has obtained a Rosalind Franklin Fellowship to establish her own research group in the Molecular Neurobiology section of the Department of Biomedical Sciences of Cells and Systems at the University Medical Center Groningen, The Netherlands. Fantastic news, Inge!
  • Aug2020
  • Congratulations to Alexi Nott who will be starting his lab with the UK Dementia Research Institute and the Department of Brain Sciences at Imperial College London. His group will be focused on understanding the role of epigenetics in driving aging-related brain disorders. Best of luck, Alexi!
  • Jul2020
  • Congratulations to Zeyang Shen et al. on their publication "MAGGIE: leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function" in Bioinformatics.

  • We are sad to say farewell to Guilherme Santos, who spent his Sabbatical year with us at the Glass Lab. He will return to his position as Associate Professor at the University of Brasília, Brazil. All the best, Guilherme!

  • We are thrilled to welcome to the Glass Lab Graduate Students Chris Balak and Eric Kofman!
  • Chris Balak will be working in the Alzheimer's/Microglia group together with Alexi Nott and Bethany Fixsen on the topic of targeted knockdown of SALL1 using antisense oligos (ASOs) in mice.
    Eric Kofman will be working with Claudia Han on analyzing the immune compartment in glioma.

  • Congratulations to Mashito Sakai on accepting a position as Professor in the Department of Biochemistry and Molecular Biology at Nippon Medical School in Tokyo, Japan. Best of luck, Mashito!

  • Visiting Research Fellow to the Glass Lab and Associate Professor at the University of Brasília, Guilherme Santos , published his career story "As a scientist working abroad, I missed my culture — so I found a way home" in Science Magazine. Take a look!
  • May2020
  • Hunter Bennett received a Ruth L. Kirchstein National Research Service Award (F30) from the National Institute of Diabetes and Digestive and Kidney Diseases to study liver macrophage LXR signaling in Non-Alcoholic Fatty Liver Disease. Congratulations, Hunter!

  • Congratulations to Jason Seidman, Ty Troutman, Mashito Sakai, Nathan Spann, Hunter Bennett et al. on their publication "Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis" in Immunity.
  • April2020
  • We are very happy to welcome Anna Warden to the Lab. Anna is a Postdoctoral Fellow who will be working with the Microglia group and the Coufal Lab. She is currently working on understanding how microglia identity and function are regulated by the microenvironment using IPSC-derived microglia and transplantation models.
  • Welcome to the Glass Lab, Jean Challacombe. Jean will provide analytical expertise, mentoring and training in bioinformatics, genomics and computational methods based on project needs. She will also conduct and supervise the development of novel methods to support the advancement of current and future research efforts in the lab.
  • Zeyang Shen and colleagues have posted their publication "Natural genetic variation affecting transcription factor spacing at regulatory regions is generally well tolerated" to BioRxiv. Congratulations!
  • Mar2020

  • Glass lab undergrad alumna Maayan Yakir matches to the UCSD Child Neurology Residency program. Congrats, Maayan!
  • Feb2020
  • Marten Hoeksema was awarded a Marie Curie fellowship to investigate the role of Egr1 and Egr2 regulating enhancer activity and inflammatory potential in macrophages. His work will increase our knowledge on how disease-associated signals regulate enhancer activity in disease relevant cell types. Congratulations, Marten!
  • Jan2020
  • Zeyang Shen and colleagues have posted their publication "MAGGIE: leveraging genetic variation to identify DNA sequence motifs mediating transcription factor binding and function" to BioRxiv. Congratulations!
  • Congratulations to Eniko Sajti et al. on the publication of their Nature Immunology paper "Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung".